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Combined (Estrogen/Progestin) Contraceptives Combined (Estrogen/Progestin) Contraceptives

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General Information | Combined Oral Contraceptives | Combined Injectable Contraceptives

METHOD Combined oral and injectable contraceptives contain both an estrogen (E) and progestin (P)

Types

Mechanisms of Action

  • Suppress ovulation
  • Thicken cervical mucus, preventing sperm penetration
  • Change endometrial lining
  • Reduce sperm transport in upper genital tract (fallopian tubes)

When to Start

  • Anytime you can be reasonably sure the client is not pregnant (see Client Assessment chapter)
  • Days 1–7 of the menstrual cycle
  • Postpartum:
    • after 6 months if using LAM
    • after 6 weeks if breastfeeding but not using LAM
    • after 3 weeks if not breastfeeding
  • Postabortion (immediately or within 7 days)
APPROPRIATE FOR
  • Women of any reproductive age or parity who want highly effective protection against pregnancy
  • Breastfeeding mothers 6 months or more postpartum (6 weeks or more if not using LAM)
  • Postpartum women who are not breastfeeding (may begin after third week postpartum)
  • Postabortion clients (may begin immediately)
  • Women with anemia
  • Women with moderate to severe menstrual cramping
  • Women with irregular menstrual cycles
  • Women with histories of ectopic pregnancy
METHOD CHARACTERISTICS: BENEFITS
  • Highly effective
  • Rapidly effective
  • Pelvic examination not required prior to use
  • Do not interfere with intercourse
  • Few side effects
  • Can be provided by trained nonmedical staff

Noncontraceptive Benefits

  • Decrease menstrual flow (lighter, shorter periods)
  • Decrease menstrual cramps
  • May improve anemia
  • Protect against ovarian and endometrial cancer
  • Decrease benign breast disease (cysts/lumps) and ovarian cysts
  • Prevent ectopic pregnancy
  • Protect against some causes of PID
METHOD CHARACTERISTICS: LIMITATIONS
  • Some nausea, dizziness, mild breast tenderness or headaches as well as spotting or light bleeding (usually disappear within 2 or 3 cycles/injections)
  • Effectiveness may be lowered when certain drugs are taken (see table Interactions with Other Drugs in this chapter)
  • Can delay return to fertility
  • Serious side effects rare (stroke, blood clots in lungs or brain and malignant liver tumors) in women using COCs
  • Resupply must be available
  • Do not protect against STDs including, HBV and HIV/AIDS

 

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METHOD Combined Oral Contraceptives (COCs)

Types (See Table 8 for specific examples)

  • Monophasic: All 21 active pills contain same amount of E/P
  • Biphasic: 21 active pills contain 2 different E/P combinations (e.g., 10/11)
  • Triphasic: 21 active pills contain 3 different E/P combinations (e.g., 6/5/10)
APPROPRIATE FOR

 

  • Women who want a combined (estrogen/progestin) contraceptive but do not want injections
METHOD CHARACTERISTICS: BENEFITS
  • Highly effective when taken daily (0.1–8 pregnancies per 100 women during the first year of use)
  • Rapidly effective (<24 hours)
  • Convenient and easy to use
  • Client can stop use

Noncontraceptive Benefits

  • More regular menstrual cycles
  • Immediate return to fertility
METHOD CHARACTERISTICS: LIMITATIONS
  • User-dependent (require continued motivation and daily use)
  • Forgetfulness increases failure
  • Women starting COCs after day 7 of the menstrual cycle should use a backup method or abstain from sex for 4 days.

 

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METHOD Combined Injectable Contraceptives (CICs)

Examples

  • Cyclofem®/Cyclo-Provera®/Lunelle®: 25 mg depot-medroxyprogesterone acetate and 5 mg estradiol cypionate injected IM once a month
  • Mesigyna®: 50 mg norethindrone enanthate and 5 mg estradiol valerate injected IM once a month

Syringe

APPROPRIATE FOR

 

Women who cannot remember to take a pill every day
METHOD CHARACTERISTICS: BENEFITS
  • Highly effective (0.1–0.4 pregnancies per 100 women during the first year of use)
  • No supplies needed by client
  • More rapid return to fertility than with progestin-only injectable contraceptives
METHOD CHARACTERISTICS: LIMITATIONS
  • Cause changes in menstrual bleeding pattern (irregular bleeding/spotting initially) in some women
  • User-dependent (client must return for injection every 30 days)

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